Comprendre le lien entre nutrition et microbiote

Les effets de fortes doses de vitamine D3 sur le microbiote intestinal associés aux muqueuses varient selon les régions du tractus gastro-intestinal humain,and%20increased%20bacterial%20richness.
Bashir, Mina et al. “Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract.” European journal of nutrition vol. 55,4 (2016): 1479-89. doi:10.1007/s00394-015-0966-2

Fonctions du microbiote intestinal : métabolisme des nutriments et autres composants alimentaires
Rowland, I., Gibson, G., Heinken, A. et al. Gut microbiota functions: metabolism of nutrients and other food components. Eur J Nutr 57, 1–24 (2018).

Analyse de la variation du microbiote intestinal au niveau de la population Falony, Gwen et al. “Population-level analysis of gut microbiome variation.” Science (New York, N.Y.) vol. 352,6285 (2016): 560-4. doi:10.1126/science.aad3503

Microbiote intestinal : L'occidentalisation et la disparition de la diversité intestinale Segata, Nicola. “Gut Microbiome: Westernization and the Disappearance of Intestinal Diversity.” Current biology : CB vol. 25,14 (2015): R611-3. doi:10.1016/j.cub.2015.05.040

Le rôle de l'alimentation dans le déclenchement des troubles inflammatoires humains à l'ère moderne Huang, Edmond Y et al. “The role of diet in triggering human inflammatory disorders in the modern age.” Microbes and infection vol. 15,12 (2013): 765-74. doi:10.1016/j.micinf.2013.07.004

Impact d'une intervention alimentaire sur la richesse génétique microbienne de l'intestin Cotillard, Aurélie et al. “Dietary intervention impact on gut microbial gene richness.” Nature vol. 500,7464 (2013): 585-8. doi:10.1038/nature12480

L’effet des probiotiques et prébiotiques sur le microbiote et la santé

L’effet des probiotiques, prébiotiques et synbiotiques sur la santé humaine,the%20gastrointestinal%20tract%20%5B180%5D. Markowiak, Paulina, and Katarzyna Śliżewska. “Effects of Probiotics, Prebiotics, and Synbiotics on Human Health.” Nutrients vol. 9,9 1021. 15 Sep. 2017, doi:10.3390/nu9091021

Probiotiques et prébiotiques dans la santé et les maladies intestinales : de la biologie à la clinique Sanders, M.E., Merenstein, D.J., Reid, G. et al. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol 16, 605–616 (2019).

Probiotiques : définition, champ d'application et mécanismes d'action Reid G. “Probiotics: definition, scope and mechanisms of action.” Best Practice & Research Clinical Gastroenterology, Volume 30, Issue 1, Pages 17-25, 2016 Feb. Web 2015 Dec 19. Accessed 2018 May 30. DOI: 10.1016/j.bpg.2015.12.001

Les études sur nos formules et souches

Transit - Formule spécialisée SII

Human clinical trial Saggioro A. Probiotics in the treatment of Irritable Bowel Syndrome. J Clin Gastroenterol, 2004; 38(8): S104-106. In vitro study Nicola S. et al. Immunomodulation properties of Lactobacillus plantarum LP01 (LMG P-21021) and Lactobacillus acidophilus LA02 (DSM 21717) blend.

Digest. - Formule spécialisée digestion

Human clinical trials on blend

  • Saggioro A. Probiotics in the treatment of Irritable Bowel Syndrome. J Clin Gastroenterol, 2004; 38(8): S104-106.
  • Del Piano et al. Evaluation of the intestinal colonization by microen- capsulated probiotic bacteria in comparison to the same uncoated strains. J Clin Gastroenterol, 2010; 44(8):S42-46.
  • Del Piano M. et al. The use of probiotics in healthy volunteers with eva- cuation disorders and hard stools. A double blind, randomized, placebo- controlled study. J Clin Gastroenterol, 2010; 44(8): S30-34.
  • Dimidi E. et al. The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2014;100:1075–84.
  • Del Piano M. et al. The use of probiotics in the treatment of constipa- tion in the elderly (BL03, LP01, BS01, LR05, BA02 and BR03 sepera- tely). CIBUS, 2005; 1(1):23-30.

Immunity. - Formule spécialisée immunité

In vitro study of strain Bifidobacterium lactis BS01 for immunity:

  • Mogna L. et al. Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization: A New Approach. J Clin Gastro- enterol. 2018;52:S57-S61.
Study of strain LR04 for FUNCTIONALITY: reinforcement of the natural defences, Reduction of the incidence, severity and duration of Acute Respiratory Infections (ARI) during the cold season
  • Human clinical trial: Pregliasco F. et al. A New Chance of Preventing Winter Diseases by the Administration of Symbiotic Formulations. Journal of Clinical Gastroente- rology, 2008; 42(2): 224-233
In-vitro study of strain LRE02 for FUNCTIONALITY Production of reuterin and vitamin B12, Anti-Pathogen activity

Mood. - Formule spécialisée gut-brain

Human clinical trial study of L. Rhamonsus GG for gut-brain:

  • Human clinical trial Anna Pärtty et al. A possible link between early probiotics intervention and the risk of neuropsychiatric disorders later in childhood: a randomi- zed trial. Pediatric Research, Volume 77, Number 6, June 2015.

B. longum BL03 gut brain study:
  • Human clinical trial Wallis A. et al. Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis / chronic fatigue syndrome: neuropsycholo- gical symptoms and sex comparisons. J Transl Med 2018, 16:24.

Fit. - Formule spécialisée fitness

In vitro study:
We chose this strain after a screening of 50 Bifidobacteria in order to select the best producer of Bile Salt Hydrolase (BSH), which decreases the transport of cholesterol from the intestine to the blood, but also, in order to maintain homeostasis in terms of transporters, obliging the system to recover cholesterol from the liver to reconstitute the bile salts and transporters. B. infantis BI02 (MB 287) is by far the strongest producer of BSH.
It has been characterized for the adsorption of cholesterol in its membrane, allowing more cholesterol to be eliminated from the intestine and bringing to 3 the mechanisms of action of this strain against cholesterol.

Nos souches probiotiques​

Nous utilisons des souches probiotiques ayant fait l'objet d'études in vitro, et d'études cliniques humaines. Voici la bibliothèque des références.